重组人神经营养因子-4
产品名称： 重组人神经营养因子-4
英文名称： Recombinant Human Neurotrophin-4
产品编号： 107-04
产品价格： 0
产品产地： 美国
品牌商标： sciencell
更新时间： 2024-10-30T10:05:13
使用范围： null
上海中乔新舟生物科技有限公司
- 联系人 : 胡小姐
- 地址 : 上海市宝山区长江南路180号A区401-406室
- 邮编 : 200433
- 所在区域 : 上海
- 电话 : 181****0148 点击查看
- 传真 : 点击查看
- 邮箱 : wwwfudan@163.com;hufangqiong@zqxzbio.com
- 二维码 : 点击查看
产品：重组人神经营养因子-4
货号：107-04
| Description | Neurotrophin-4 (NT-4) is a member of the NGF family of neuronal and epithelial growth factors. Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. Human NT-4 shares 48 - 52% amino acid (aa) sequence identity with human beta-NGF, BDNF, and NT-3. It shares 91% and 95% identity with mouse and rat NT-4/5, respectively. The mature protein is secreted as a homodimer and can also form heterodimers with BDNF or NT-3. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 promotes the development and survival of selected peripheral and CNS neurons. NT-4 induced TrkB signaling augments NMDA receptor activity and increases neuronal sensitivity to excitotoxic cell death. It also promotes the proliferation of keratinocytes and accelerates hair follicle regression during the follicular cycle. NT-4 is secreted by activated T cells and granulocytes at sites of inflammation where it contributes to tissue regeneration. |
| Synonyms | NT-5, GLC10, GLC1O, NT-4/5 |
| AA Sequence | GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETRC KADNAEEGGP GAGGGGCRGV DRRHWVSECK AKQSYVRALT ADAQGRVGWR WIRIDTACVC TLLSRTGRA |
| Source | Escherichia coli |
| Molecular Weight | Approximately 28 kDa, a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers (260 total amino acid residues). |
| Biological Activity | Fully biologically active. The ED50 is is 20-50ng/ml, as determined by choline acetyl transferase activity in rat basal forebrain primary septal cell cultures |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated (0.5mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
| Storage | Store at -20°C after receiving. Upon Reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Usage | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Growth Factors and Cytokines | |||
| Human Growth Factors | |||
| 102-01 | rhSCF | 重组人干细胞因子 | Recombinant Human Stem Cell Factor |
| 102-02 | rhG-CSF | 重组人粒细胞集落刺激因子 | Recombinant Human Granulocyte Colony Stimulating Factor |
| 102-03 | rhGM-CSF | 重组人粒细胞巨噬细胞集落刺激因子 | Recombinant Human Granulocyte Macrophage Colony Stimulating Factor |
| 102-09 | rhM-CSF | 重组人巨噬细胞集落刺激因子 | Recombinant Human Macrophage Colony Stimulating Factor |
| 103-01 | rhTNF-α | 重组人肿瘤坏死因子-α | Recombinant Human Tumor Necrosis Factor-alpha |
| 103-01H | rhTNF-α-His | 重组人肿瘤坏死因子-α,His | Recombinant Human Tumor Necrosis Factor-alpha,His |
| 103-01V | rhTNF-α Vari | 重组人肿瘤坏死因子-αVariant | Recombinant Human Tumor Necrosis Factor- alpha Variant |
| 103-04 | rhBAF | 重组人B细胞活化因子 | Recombinant Human B Cell Activating Factor |
| 103-08 | rhOSM | 重组人抑瘤素-M | Recombinant Human Oncostatin-M |
| 103-08T | rhOSM 209a.a. | 重组人抑瘤素-M209a.a. | Recombinant Human Oncostatin-M 209a.a. |
| 103-09 | rhAK1-3 | 重组人血管抑素K1-3 | Recombinant Human Angiostatin K1-3 |
| 103-12 | rhEndostatin | 重组人血管内皮抑素 | Recombinant Human Endostatin |
| 104-01 | rhaFGF | 重组人碱性成纤维细胞生长因子--酸性 | Recombinant Human Fibroblast Growth Factor- acidic |
| 104-02 | rhbFGF | 重组人碱性成纤维细胞生长因子--碱性 | Recombinant Human Fibroblast Growth Factor-basic |
| 104-07 | rhKGF-1 | 重组人角质细胞生长因子-1 | Recombinant Human Keratinocye Growth Factor-1 |
| 104-09 | rhFGF-9 | 重组人成纤维细胞生长因子-9 | Recombinant Human Fibrobalst Growth Factor-9 |
| 104-10 | rhKGF-2 | 重组人角质细胞生长因子-2 | Recombinant Human Keratinocye Growth Factor-2 |
| 104-19 | rhFGF-19 | 重组人成纤维细胞生长因子-19 | Recombinant Human Fibrobalst Growth Factor-19 |
| 104-21 | rhFGF-21 | 重组人成纤维细胞生长因子-21 | Recombinant Human Fibrobalst Growth Factor-21 |
| 105-01 | rhIGF-I | 重组人IGF-I | Recombinant Human IGF-I |
| 105-01B | rHuDES1-3/IGF1 | 重组人 DES1-3/ 胰岛样生长因子 -1 | Recombinant Human DES1-3/ Insulin-Like Growth factor 1 |
| 105-01B3 | rhIGF-BP3 | 重组人 IGF-BP3 | Recombinant Human IGF-BP3 |
| 105-03 | rhLR3IGF-1 | 重组人长R3胰岛样生长因子-1 | Recombinant Human Long R3 Insulin-like Growth factor-1 |
| 105-04 | rhEGF | 重组人表皮细胞生长因子 | Recombinant Human Epidermal Growth Factor |
| 105-05 | rhVEGF165 | 重组人血管内皮生长因子165 | Recombinant Human VEGF165 |
| 107-04 | rhNT-4 | 重组人神经营养因子-4 | Recombinant Human Neurotrophin-4 |
| 107-08 | rhCNTF | 重组人睫状神经营养因子 | Recombinant Human Ciliary Neurotrophic Factor |
| 107-10 | rhNRG-1 | 重组人 NRG-1（表皮生长因子样结构域） | Recombinant Human NRG-1(EGF-like domain) |
| 107-11 | rhErbB3-f | 重组人ErbB3片段 | Recombinant Human ErbB3 Fragment |
| 107-12 | rhBTC | 重组人乙胞素 | Recombinant Human Betacellulin |
| 108-02 | rhBMP-2 | 重组人骨形成蛋白-2 | Recombinant Human Bone Morphogenetic Protein-2 |
| 108-04 | rhBMP-4 | 重组人骨形成蛋白-4 | Recombinant Human Bone Morphogenetic Protein-4 |
| 108-07 | rhBMP-7 | 重组人骨形成蛋白-7 | Recombinant Human Bone Morphogenetic Protein-7 |
| 108-08 | rhOPG-Fc | 重组人骨保护素Fc融合蛋白 | Recombinant Human Osteoprotegerin/Fc Chimera |
| 108-09 | rhNOGGIN | 重组人NOGGIN蛋白 | Recombinant Human NOGGIN |
| 301-01 | rhGH | 重组人生长激素 | Recombinant Human Growth Hormone |
| Growth Factors and Cytokines | |||
| Mouse Growth Factors | |||
| 122-03 | rmGM-CSF | 重组鼠粒细胞-巨噬细胞集落刺激因子 | Recombinant Murine Granulocyte- Macrophage Colony Stimulating Factor |
| 123-01 | rmTNF-α | 重组鼠肿瘤坏死因子-α | Recombinant Murine Tumor Necrosis Factor-alpha |
| 123-07 | rmLIF | 重组鼠白血病抑制因子 | Recombinant Mouse Leukemia inhibitory factor |
| 124-02 | rmbFGF | 重组鼠成纤维细胞生长因子-碱性 | Recombinant Murine Fibroblast Growth Factor-basic |
| 124-07 | rmFGF-7/KGF | 重组鼠成纤维细胞生长因子-7 | Recombinant Mouse Fibroblast Growth Factor-7 |
| 125-04 | rmEGF | 重组鼠表皮细胞生长因子 | Recombinant Murine Epidermal Growth Factor |
| 125-06 | [rmVEGF120 | 重组鼠血管内皮生长因子120 | Recombinant Murine Vascular Endothelial Growth Factor 120 |
| 125-07 | rmVEGF165 | 重组鼠血管内皮生长因子165 | Recombinant Murine Vascular Endothelial Growth Factor 165 |
| 128-09 | rmNOGGIN | 重组鼠NOGGIN | Recombinant Murine NOGGIN |
| 221-16 | rmCXCL16 | 重组鼠CXCL16 | Recombinant Murine CXCL16 |
| Growth Factors and Cytokines | |||
| Rat Growth Factors | |||
| 142-03 | rrGM-CSF | 重组鼠粒细胞-巨噬细胞集落刺激因子 | Recombinant Rat Granulocyte- Macrophage Colony Stimulating Factor |
| 143-01 | rrTNF-α | 重组鼠肿瘤坏死因子-α | Recombinant Rat Tumor Necrosis Factor-alpha |
| 144-02 | rr bFGF | 重组鼠成纤维细胞生长因子-基础 | Recombinant Rat Fibroblast Growth Factor-basic |
| 145-01 | rrIGF | 重组鼠IGF-I | Recombinant Rat IGF-I |
| 145-04 | rbEGF | 重组鼠表皮细胞生长因子 | Recombinant Rat Epidermal Growth Factor |
| Growth Factors and Cytokines | |||
| Cow Growth Factors | |||
| 154-02 | rbCXCL16 | 重组牛碱性成纤维细胞生长因子 | Recombinant Bovine Basic Fibroblast Growth Factor |
| Growth Factors and Cytokines | |||
| Protein Growth Factors | |||
| 1001-01 | rProteinA | 重组蛋白A | Recombinant Protein A |
| 1002-01 | rProteinG | 重组蛋白G | Recombinant Protein G |
| 1002-02 | rCysProteinG | 重组半胱氨酸-蛋白G | Recombinant Cys-Protein G |
| 1003-01 | rProteinA/G | 重组蛋白A/G | Recombinant Protein A/G |
| 1005-01 | rStreptavidin | 重组链霉亲和素 | Recombinant Streptavidin |
| HY01 | OsrHSA | 重组人血清白蛋白 | Recombinant Human Serum Albumin |
|
Sciencell公司产品由上海中乔新舟生物科技有限公司优质供应 近几年的新药研发成功率在逐年下降，其根本原因之一就是传统的药物筛选系统是建立在只具有30-40%人类基因群的一系列细胞株上。这样一个有“缺陷型”药物筛选系统所产生的药物用于人体上就会出现许多致命的弱点和不完整性。新一代药物筛选系统是含有一系列近乎完整的人类基因群的原代细胞株。而利用这些原代细胞株所甄别和筛选出来的候选药物，其诊治人类疾病的成功几率将大大增加。这样不但大大节省了新药的开发成本，而且将极大地提高人类的健康质量。这些产品从根本上提高了全球生命医学研究、人类重要疾病药物研发、新药研发的成功率。所以上海中乔新舟生物科技有限公司致力于提供优质原代细胞产品和完善的售后服务。 美国ScienCell研究实验室（www.sciencellonline.com）成立于1999年，公司总部位于美国加州的圣地亚哥。主要致力于实验室科研用原代细胞、原代细胞专用培养基、原代细胞无血清培养基、干细胞、干细胞培养基、干细胞无血清培养基的研究和开发，在全球拥有众多客户。在国内销售15年来，很多老师应用其产品发表了高质量的SCI文章，凭借着严格的质控和优秀的产品品质，深受广大科研工作者的信赖。 ScienCell研究实验室生产的原代细胞、原代细胞专用培养基都经过了严格的质量控制，细胞纯度可达98％。其中包括21种人体正常细胞系统，90多种不同细胞类型。大多数细胞在全球唯有ScienCell实验室能够成功分离，产品质量过硬。 确保了实验结果的真实性、重复性和连贯性。 Sciencell公司部分原代细胞目录（如需要其他细胞资料请发邮件至 wwwfudan@163.com索取）： 中乔新舟www.zqxzbio.com专长于为生物医药领域的医疗机构、研究中心、企业、临床医生等提供课题设计、基金联合申请、实验技术服务、论文相关服务、采购外包等整体服务，目前已经成长为国内领先的转化医学外包品牌。 中乔新舟的PI团队已经发展到专职PI 20人，联席PI 312人，其中大多数拥有海外背景。截止到2009年3月，以PI或联席PI为第一作者发表SCI 论文1682 篇（总IF 值为5721.82，其中影响因子IF>5.0 的论文216 篇，IF>10.0论文32 篇）。 电话：021-51262076 13371892488 Email:wwwfudan@163.com QQ：739782475 网址：www.zqxzbio.com |
上海中乔新舟生物科技有限公司是美国Sciencell公司官网公布的一级代理商：